Booth and Brennan head across the pond to the UK where Brennan guest lectures at Oxford while Booth speaks at Scotland Yard. While there, local officials ask for their help on a high-profile murder case involving a British heiress.

While in London, Booth and Brennan aid in a murder investigation where they team up with Dr. Ian Wexler and Inspector Cate Pritchard. Back in D.C., the Jeffersonian team leads their help in the case, but is surprised when Angela's long-estranged husband returns.

After a decomposed body of the host of a popular reality show is found in an outhouse, Booth and Brennan must track down the killer out of a large group of suspects, most of which were humiliated on the victim's TV show. Meanwhile, Booth tries to comprehend Brennan's romantic life after he finds out she is involved in two relationships.

When Parker finds a severed finger in a bird's nest while playing with Booth, the team gets together to find the rest of the body. After the body is found in Jefferson Memorial Park, it is revealed that the death was a murder. With the help of a new grad student, the team is able to identify the body as a local veterinarian with a gambling problem. This fact leads them to an illegal dog fighting ring where, with the help of Cesar Millan, the team is able to gather enough evidence to track down the killer.

When a teenager comes across a dismembered body in a pool of purple water, Brennan and Booth are called to the scene. There they find that the victim's head is missing. With help from the newest grad student, Wendell, the team learns the body is that of Jared Addison, a 25-year-old science fiction writer with severe OCD. Sweets lends his expertise to the case as Booth and Brennan interview suspects, which includes Jared's psychologist. Meanwhile, a person from the group's past gives them insight into the case.

When the remains of a manager are found in an office building's elevator shaft, Booth and Brennan must attempt to find which employee had the most motive to kill their boss. Meanwhile, Brennan's latest grad student, who has a very bleak and morbid outlook on life, lends his insight.

When remains are found in the Chesapeake Bay, Booth and Brennan are sent to the scene to investigate. The team has little to go on when only the upper torso is found, complete with breast implants. However, when the lower half is found, everyone realizes their initial assumptions about the victim were incorrect.

A skull is found in an impounded junkyard car and Booth and Brennan must uncover whether or not foul play was involved. They soon discover that the remains are that of a famous artist and the suspects range from rival artists to his own assistant who stands to inherit everything upon his death. Meanwhile, Angela's ex-girlfriend becomes a suspect in the case, leading Angela to go to any lengths to prove her ex's innocence.

Booth's brother, Jared, and Brennan investigate after a body is found uring a police raid. The team learns the victim is an inventor's father who had a difficult past with his son. But when a second body is found, the team must race to find the con man in the inventor's life. Meanwhile, Brennan goes on a date with Booth's brother and learns a lot about Booth's past.

Booth and Brennan travel to China to help identify pre-historic remains, but while on the flight, a human body is found in the plane. In order to solve the crime, Booth and Bones must get equipment from the passengers in order to piece together a device to send evidence back to The Jeffersonian before they lose jurisdiction. Back in the U.S., Hodgins begins to move on after his break-up with Angela, while Angela and Roxie grow closer.

Brennan and Booth investigate when several skeletal remains are found on protected grounds. The team uncovers that the remains are that of an ex-Marine who has been AWOL for 3 years. Clues leads Booth and Brennan to an elite private school where the ex-Marine had worked as a "manny" for one of the rich families.

Booth and Brennan are sent to the Texas-Oklahoma border to investigate the murder of conjoined twins found in a shallow grave in the desert. At the lab, the team determines the remains belong to Jenny and Julie, jugglers for a traveling circus. In order infiltrate the circus community, Booth and Brennan go undercover as a knife-throwing act "Buck and Wanda Moosejaw" to find the story behind their murder.

After a volunteer fireman is found dead at an ice rink, Booth and Brennan are called to investigate. However, when information surfaces that Booth may have a conflict of interest in the case, he is removed from the investigation and becomes a suspect himself.

When Booth is kidnapped by the Grave Digger, the team at the Jeffersonian must race against the clock to save him before it's too late. Meanwhile, evidence from the case goes missing and Brennan and Hodgins are suspected of stealing it.

Bones and the team are called to investigate when a woman is murdered during a sci-fi convention. While Booth is out with an injured back, Agent Payton Perotta arrives to help with the investigation.

When newlyweds encounter a corpse while bungee-jumping off of a bridge, Brennan and Booth are sent to investigate. After determine the cause of death was not suicide, the team at the Jeffersonian discover an unknown substance coming from the body. This sends the lab into lockdown and have only 24 hours to uncover the murderer before the body disintegrates.

Booth and Brennan are called when a human body is found buried in a mound of salt onboard a de-icing truck. They find the victim was a pregnant 16-year-old high school student and soon learn that half of her teammates on the school volleyball team were part of a secret "pregnancy pact."

When the half-eaten body of Cam's former fiancee is found in the tiger cage at the zoo, Booth and Brennan uncover that his death was far from accidental. Now the team must put the pieces of the fiancee's final day back together, including hypnotizing a suspect in order to spark his memory.

Booth and Brennan are sent to investigate when human remains are found during a photo shoot. When the team uncovers a meteorite in the victim's ear, they are led to the Collar Institute of Science in D.C. There they learn the victim had been a part of a controversial project, Brennan and Booth must investigate the several death threats she had received. Meanwhile, Angela's father arrives in town to confront Hodgins.

Booth and Brennan are called when an image of the Virgin Mary is found in a bale of compressed cardboard. They find that the image is in fact a bloody outline of a body that has been flattened inside of the cardboard bale. Once the victim is identified, Booth and Brennan retrace her final moments and find the vicitim was involved in shady relationships. Meanwhile, Booth and Brennan become suspicious when they see Daisy, Sweets' girlfriend, trying on wedding dresses with another man; and Hodgins and Angela come to terms with their relationship.

When it is discovered that a stage prop used by a Norwegian death metal band is in fact a real human skeleton, the remains are sent to the Jeffersonian when authorities determine the vicitim was an American citizen. The team links the skeleton to a U.S. death metal band and Booth and Brennan must venture into the death metal music scene in search of the killer. Meanwhile, Sweets goes to Dr. Gordon Wyatt for input on a book he's writing about Booth and Brennan, and Dr. Wyatt gives him a new perspective on the duo's relationship.

When a Jeffersonian coworker dies of heart failure, the entire team goes to the wake where, upon viewing the body, Brennan realizes the death was no accident. Brennan then convinces Booth to help her steal the body, leading them into a bizarre mystery surrounding the actual cause of death. Meanwhile, Cam gets a crash-course in parenting when she must convince her newly adopted daughter to quit smoking.

Booth's detective friend from Tokyo, Ken Nakamura, calls him when his sister, Sachi, goes missing while in Washington, D.C. With Brennan, Booth investigates her disappearance and soon find a canal in which they discover Sachi's decapitated head. Ken arrives in Washington and Booth and Brennan work with him to retrace his sister's final moments to find her killer.

The team is called to investigate when the body of a frat boy is found inside of a college mascot uniform following a pep rally. Meanwhile, Booth offers to help Jared, his brother, find a new job.

After a body of a wine critic is find inside of a barrel of wine, the team investigates and soon find that the critic gave a bad review that lead to the closure of a vineyard. Meanwhile, Booth finds out he has a health problem, and Brennan, making matters worse, informs him that she wants to have his baby.

A body is found murdered at "The Lab," a nightclub, and everyone is a suspect in a unique season finale in which Brennan, Booth and the team all take on various roles outside of their normal duties.