In a take off of the scifi show “Sliders” (1995-2000), Stewie and Brian travel to different versions of Quahog.

When Lois finds a lump on her breast, she goes to the doctor to test for cancer.
The tests come back benign, but the doctor looks at her family medical history and reveals some news about Lois' heritage.
Peter takes to the family's new found faith eagerly, but when he is visited by the ghost of his father, he changes his tune.
After a visit from an old friend sets him straight, Peter and Lois agree to go back to the way things were

Chevy Chase and Dan Aykroyd (starring as themselves) move to Spooner Street and hit it off with the Griffins culminating in Stewie and Brian becoming involved with a spy mission in Russia.

Brian dates an older woman despite the ribbing he gets from his family.

It only gets worse when he's forced to become her errand boy after she breaks her hip.

Stewie attends a concert of a teen superstar and discovers a surprising secret about the singer.

Meanwhile back at home, Chris tries to prove to the family that the Evil Monkey is real.

Father doesn’t know best when Quagmire assumes responsibility for a baby Peter finds who looks just like him.

Meanwhile, Stewie clones himself in an all-new episode that also features a guest voice by Brittany Snow.

Realizing they need to find a replacement for Cleveland, the guys decide they need another black guy.
They happen to meet Jerome who fits in perfectly only to find out he has a history with Lois.

Meanwhile, after Brian volunteers to be the group's fourth, he finds out Glen hates him.

When Brian accidentally kills another dog, he is surprised to see that no one cares, so he tries to convince everyone that the life of a dog should have the same value as a human one.

Meanwhile, Lois hires a maid who doesn’t listen to Peter

When Peter gives Lois’ father the bachelor party he never had, Mr. Pewterschmidt slips into a coma and not even Dr. House (guest voice Hugh Laurie) can bring him out of it.
With her father incapacitated, Lois is given control of Pewterschmidt Industries. Peter convinces Lois to let him run the operation, but he gets power-hungry and fires the board.
Mr. Pewterschmidt soon bounces back and tries to regain control of what he’s built – even though it may be more difficult than Christmas shopping for Peter

After Peter hits his head and develops amnesia, he forgets everything, including his family and his friends.

Lois takes extra care of Peter and tries everything to jog his memory and until he starts hitting on other women.

Fed up with his antics, Lois takes the kids and leaves, giving Quagmire his opportunity to swoop in and score.

Brian gets a gig writing for a teen magazine about the average American girl, but when he starts trailing Meg for research he discovers that her desperate attempts at dating have led her to a guy in the slammer. When Brian tries to expose Meg’s secret to the family, he finds that her boyfriend, Luke, has broken out of jail and has been hiding in the Griffin’s house.

Source: FOX

When Chris and Stewie go missing for several days, Lois is at her wit’s end until she sees a psychic who assures her they are safe. Even after the boys return home, Lois and Peter’s psychic obsession continues, and Peter takes it a step too far when he starts charging neighbors for his extrasensory perception. Meanwhile, Chris develops a crush on a girl at school.

Source: FOX

Stewie pulls a “Tootsie” in order to star in the American version of Jolly Farm Review.

Meanwhile, Peter makes Lois feel bad about her age, and she gets a bit jealous of Meg’s new boyfriend.

Source: Freakin' Sweet News

After Peter has some luck selling footage of a celebrity he caught off-guard, he decides to become a full-time paparazzo. To make matters worse, his new boss, Angela, finds him irresistible and plagues him with unwanted advances. When Peter rebuffs her, he winds up getting the ax. Meanwhile, Stewie makes his theatrical debut in a school play, only to be overcome with stage fright.

Source: FOX

When Lois reads Brian’s pilot script, she falls in love with it and insists that he meet with network executives to pitch it.
The execs respond positively, and the initial casting session goes well with Elijah Wood (guest-voicing as himself) auditioning for the lead role.
But when the suits insist that Brian hire James Woods (guest-voicing as himself) and change the entire concept, Brian finds himself caught between a rock and a hard place.

Meanwhile, Chris and Meg seriously injure Stewie and try to cover it up

Source: FOX

When the local news announces that the Earth will be destroyed by a black hole in 24 hours, everyone in Quahog goes nuts trying to live out their last day.
In the mayhem Peter reveals his true feelings about his family.

In the 150th episode, Brian & Stewie get locked in a bank vault, they are forced to deal with each other on a whole new level.

Unlike any other FAMILY GUY episode, the acts will play out in real time as Brian and Stewie react to being locked in a small space with no baby food or martinis to keep them from losing their minds while they hatch an escape plan

Source: FOX

Glen's father, Dan Quagmire, pays him a visit only to reveal a startling secret.

Peter and the gang’s search for the historical source of all dirty jokes leads them to Virginia where they reunite with Cleveland and meet his new family

Source: Freakin' Sweet News

Peter makes good on another power outage at home--by entertaining his family with a retelling of Star Wars Episode V: The Empire Strikes Back. Newcomers to the story include Mort as Lando Calrissian, Chris' boss Carl as Yoda, and the Giant Chicken as the nefarious Boba Fett.

Watch the “Something, Something, Something Dark Side” Trailer

Source: FOX

While at her 20th college reunion, Lois meets up with her friend Naomi who asks Lois and Peter for a big favor.
Naomi and her husband Dale ask Lois is she will be a surrogate mother to their child.

Lois agrees to carry their child but after she becomes pregnant, Dale and Naomi are killed in a car crash so she must make the difficult decision whether to terminate the pregnancy or carry to term.