House is back to work after his gunshot wounds and insists on dealing with two cases which involve paralysis. However, his life-threatening wounds have left House with a new outlook on life that leave his co-workers suspicious of his motives.

House takes on the case of a 7-year old boy who claims to be the subject of alien abduction and experimentation. Meanwhile, Cuddy and Wilson conspire to convince House that his last diagnosis was incorrect in the hope that he might learn some humility.

House and the team take on the case of a medical researcher who is suffering from an unidentified debilitating case that proves life-threatening despite the hospital's best efforts. Meanwhile, House is forced to return to using his cane when the new treatment for his leg proves less than successful.

House sympathizes with a 10-year-old autistic boy who screams loudly for no reason, but his co-workers soon wonder if House empathizes with the boy because he has no social graces either. Meanwhile, House spars with Cuddy over the remodeling of his office, and deals with a teenage crush.

A 20-year-old female patient, Tracy Dawson, arrives at the hospital with with breathing difficulties and intense abdominal pain after a robbery. However, her husband starts displaying the same symptoms and the team suspects the couple's illnesses are related. Meanwhile, antagonizing the wrong patient in the clinic.

An immensely overweight man is brought in after he's found at home in a coma. Upon regaining consciousness, he demands to be released. When Cameron comes up with a way to force him to stay, the man insists the find a reason for his illness other than his obesity. Meanwhile, Det. Tritter arrests House, searches his home, and questions his co-workers about his Vicodin usage.

Gabe, a 10-year coma patient, receives a visit from his son Kyle. When House induces a coma in Kyle, he realizes the boy may be suffering from a genetic condition, and has to turn to Gabe for answers. Meanwhile, Tritter puts pressure on Chase, Cameron, and Foreman to reveal what they know about House's abuse of drugs.

A young man forced to raise his younger siblings has to choose between a necessary medical treatment and keeping his family together. Meanwhile, Tritter goes after Wilson in his quest to bring charges against House.

Divorced parents argue over how to treat their daughter, who seemingly has pancreatitis. House takes them to court on behalf of the hospital to force the treatment he believes she needs. Meanwhile, Tritter continues to try and find something against House, and goes to obsessive lengths to do so.

Wilson betrays House to Tritter in the belief that House will finally gets the help he needs. House refuses, and Cuddy is forced to cut off House's Vicodin supply, leaving him unable to deal with a 15-year-old little person who entered the hospital with a collapsed lung and anemia, and whose condition soon deteriorates.

House must make a tough decision to avoid going to jail, while a firefighter refuses to reveal the secret that may save his life.

House has beaten the drug charges and is back at the hospital after a short stint in rehab. Cuddy comes to collect on House's debt for perjuring herself on the stand and keeping him out of jail. She forces House to pay off the debt in clinic hours, requiring him to carry out a series of less-than-desirable patient exams in the clinic. Tired of House's incessant whining about his disdain for the patients, Cuddy turns his clinic duty into a game, with the stakes raised to a level that speaks to House: money. At the clinic, House encounters patient Eve, who has tested positive for an STD and admits she's very recently been raped. Knowing he can't do anything more for Eve medically, House refers her to a psychiatrist, but she refuses to talk to the doctor and will only be treated by House. He repeatedly tries to dismiss himself from her case, but finds himself forced to unravel a very different puzzle than the sort he's used to and is compelled to come to terms with events in his own life in order to help Eve make sense of her own. Meanwhile, at the clinic Cameron encounters a homeless man with terminal cancer who, in spite of her pleas to let her ease his suffering, admits to her his basis for refusing pain medication during his final hours.

Source: FOX

16-year-old Stevie Lipa is admitted to Princeton Plainsboro Teaching Hospital with a serious respiratory condition and internal bleeding. Oddities of his case land him under House and the team's care, but at the moment, House is irritated to learn that new hospital researcher Dr. Julie Whitmer has been assigned his handicapped parking spot by the hospital entrance. Since she's in a motorized wheelchair (and he has to walk), he asks her to give up the parking spot, but she refuses. House, determined to get a parking spot closer to the hospital entrance, appeals to Cuddy, who dares him to prove how much he wants the spot by spending one week in a wheelchair, a bet House takes on. As the team tries to get personal history information from Stevie, they can't seem to get a straight answer out of him, and it's revealed he's from a family of gypsies. Stevie's parents arrive with homeopathic remedies; they won't consent to House and the team's suggested course of action, and refuse all modern medical treatment. As Stevie's body continues to bleed internally, Foreman makes the risky decision to sidestep Stevie's parents and appeals directly to the teenage patient, putting his medical license on the line while asking Stevie to lie to his parents.

Source: FOX

Its Valentines Day at Princeton-Plainsboro and the ER is short-staffed due to a snowstorm. House encounters Foremans latest patient, Hannah, who has sustained injuries from a car accident with her mother, Abby. House notices that despite her best efforts to act injured, Hannah is not feeling a bit of pain. House determines that Hannah has an incredibly rare condition that makes her completely insensitive to pain, and he takes a special interest in her case. He orders further testing to see if Hannah has any serious injuries from the car accident that she may not be able to feel, including an unnecessary procedure that causes Cuddy and Wilson to question his motives. Meanwhile, Abby undergoes surgery for her own injuries sustained in the car accident. Hannah refuses further examination and demands to see her mother, but House has little sympathy. She and House argue about which of their lives is worse, Hannah who is impervious to pain or House who suffers from pain constantly. When Hannah passes out and her temperature spikes, the doctors realize that Hannah is much sicker than they had thought. The team takes drastic measures in an attempt to inflict pain on Hannah to measure her pain threshold, but her condition only worsens. House adamantly pushes for a spinal nerve biopsy that could leave her paralyzed, a risky procedure in which few see the benefit, especially Cuddy and Wilson, who accuse House of pushing the test to get information that may benefit his own pain management. As Hannahs body deteriorates without her so much as flinching, House works through his own chronic pain to find out why this young woman cannot feel any pain at all.


Source: FOX

Patrick Obyedkov, a 35-year-old musical savant, is in the middle of playing a piano concert when he suffers a painful involuntary muscle contraction in his left hand. After Patrick is admitted to Princeton-Plainsboro Hospital with a rare movement disorder, his case attracts the attention of Dr. House. House learns from Patrick’s father, Dr. Obyedkov, that Patrick suffered severe brain damage at age 10 from a bus accident that also killed his mother. House is intrigued as to why Patrick, who was a healthy 10-year-old at the time of his accident with no prior musical training, could. suddenly play the piano flawlessly after suffering a severe injury. He pushes for further testing on Patrick’s brain even though the team has diagnosed him with a simple muscle-contraction problem. While trying to deduce the origin of the brain rewiring responsible for Patrick’s mysterious gift of music, House and his team must stop the deadly bleeding that is quickly threatening his life. Patrick’s condition worsens as he suffers an onset of seizures, and as the team attempts to stabilize him, House presents a very difficult option to Patrick’s father – a neurological procedure that would change Patrick’s life forever. In the meantime, Cameron discovers that House has been in contact with a hospital in Massachusetts and suspects that House may be looking to take a new job there. When Cuddy contacts the hospital, she learns that House has been in contact with a brain cancer specialist – not as a job applicant, but as a patient for a clinical trial. When confronted by his team, House denies the gravity of the situation and resents their interference, and they are forced to contend with the possibility his condition may be more serious than he’s letting on.

Source: FOX

House is bewildered yet intrigued when he meets his newest patient, John Kelley, an ex-Marine who had saved Houses life in a very realistic dream the night before. House is puzzled about how this man could have appeared in his dream before he met him.

Recently returned from a two-year deployment in Iraq, Kelley is complaining of fatigue, pain and other non-specific ailments he thinks are the result of Gulf War Syndrome. Just like the V.A. doctors before them, the team is wary about the validity of Kelleys symptoms, but since his uncle is an important benefactor to the hospital, they continue to investigate his case.

Meanwhile, House is suffering from ailments of his own he is unable to urinate, most likely a side effect of his Vicodin abuse, and is sleep-deprived. Unable to concentrated on the case, he eventually turns to Wilson for an under-the-table prescription.

While administering tests in the sleep lab, Cameron and Chase forego their clinical duties when they find each other (and a bed in the sleep lab) much more exciting. A foul infection shows up in Kelleys mouth while Cameron and Chase were supposed to have been on the clock, and his condition only worsens as he begins to lose his hearing, sight and mobility.

A brain scan reveals tumors in Kellys brain that were not there a week earlier when the government doctors at the V.A. examined him. When traces of uranium show up in Kelleys test results, the teams wonders if the government had something to hide,

Source: FOX

A famous, 42-year-old, pregnant photographer, Emma Sloan, is brought to the hospital after suffering a stroke in the middle of a high-profile photo shoot with Tyson Ritter. Although Emma's condition initially stabilizes, her health takes a turn for the worse when her kidneys inexplicably fail. As her health continues to deteriorate, Emma is more concerned about her baby's well-being than her own.

With no other viable explanation for the kidney failure, House realizes Emma may have a rare condition called Maternal Mirror Syndrome, in which the mothers health mimics the distress level of her fetus.

Meanwhile, Cameron and Chases secret relationship is exposed to Foreman and Cuddy, and House makes extravagant plans to take a much-needed vacation.

House calls Cuddy on the fact shes taken a special interest in the case as she identifies with Emma's struggle to have a child later in life, but her compassion for Emma may be clouding her judgment in the case. When Emma's liver begins to fail, House presents her with the heart-wrenching choice to terminate her fetus or die herself. But with Cuddy on her side, Emma demands they come up with another option an option that may not exist. With Cuddy and House at odds over how to handle her case, Emma faces a life-and-death situation for both herself and her unborn child.

Source: FOX

House and Cuddy board a flight back to the United States from Singapore, where they were speakers at an international conference. Shortly after takeoff, a passenger seated next to House becomes violently ill. While House brushes it off as a hangover, Cuddy suspects the man might have a deadly contagious virus and the other passengers could be at risk. Assuming the worst, Cuddy suggests the plane turn back and land, but House dissuades the flight attendant and the flight continues on. As the man's condition worsens, the rest of the passengers on the flight become increasingly uneasy, and so does House when a second passenger falls ill with the exact same rash and debilitating symptoms.
Back at Princeton-Plainsboro, Wilson leads the team when they encounter Fran, a middle-aged woman who collapsed at her home and soon goes into seizures. Cameron and Chase investigate Fran's house to look for clues to a diagnosis, but they are distracted by the prospect of an empty house and an inviting bed. When they return empty-handed and Fran's health continues to decline, the team must focus on finding out what is killing Fran without House's help. Back on the flight, with First Class turned into a makeshift isolation area, House calls upon a misfit team of passengers to fill in for his own team, as he bounces questions and theories off of them. When Cuddy collapses and several more passengers fall ill, the situation turns dire as the plane is hours away from any viable landing place. Without the help of his team or even proper medical equipment, House finds himself with Cuddys life and a plane-full of passengers lives in his hands.


Source: FOX

The team takes on the case of 6-year-old Lucy, who collapsed at daycare. They discover that the tissues surrounding Lucy's heart have hardened and are strangling her heart, a condition usually found in much older patients. As the team searches for an explanation, Lucy's condition worsens and she suffers a stroke.

There's a palpable tension between Cameron and Chase, and House intentionally assigns them tasks to do together, including a trip to Lucy's house to check for any possible environmental explanations for her condition. While there, they discover surprising evidence indicating that Lucy may have been abused.

Lucy's 8-year-old brother develops a not-so-innocent crush on Cameron, and as he becomes increasingly aggressive, House suspects that whatever is killing Lucy has begun to affect her brother, too. As they try to narrow down what is causing Lucy's condition before its too late, House and Cameron clash over how to treat her.

Meanwhile, when Wilson takes Cuddy out to see a play, House puts ideas in Wilson's head regarding Cuddy's motivation for going with him.

Source: FOX

The team takes on the case of Lupe, a young female scam artist who passes out while working a card-playing scheme on the streets. Lupe suffers from a lack of blood to the brain which had temporarily paralyzed her ability to make decisions or exercise free will. Measuring from her background, Foreman immediately suspects Lupe's condition stems from drug abuse, while Chase looks for other possibilities, such as toxins, in Lupe's apartment.

Lupe senses Foreman's disdain for the decisions she's made in her life, and Foreman grapples with his own humble past when his parents come to visit him. When Lupe's symptoms worsen and her organs begin to shut down, Foreman and the team suspect cancer to be the culprit.

Meanwhile, Cuddy and Wilson go out on a date to see an art exhibit together, and House probes Wilson's ex-wife about Wilson and his dating habits.

When the team learns some devastating news about Lupe's condition, they realize that their own decisions, rather that Lupe's, may cost Lupe her life.

Source: FOX

Wilson prepares his 14-year-old leukemia patient, Nick, for a last-resort bone marrow transplant from his younger brother, Matty. With Nick's immune system completely wiped out from chemotherapy, Wilson is extremely cautious about keeping him healthy before the transplant. However, when Matty sneezes during a pre-op visit to his brother, Wilson knows that Matty is not healthy enough to donate. House and the team race to find out what is making Matty sick so that they can treat him quickly and allow him to donate healthy, uninfected bone marrow to his dying brother. With no other matching donors available, the team knows that Matty is their best shot at saving Nick's life, since giving Nick bone marrow from a partial-match donor could lead to an excruciating death if Nick's body rejected it. House decides they must purposefully make Matty sicker and use his developing symptoms as a method of narrowing the diagnosis field. As both brothers' conditions worsen and Nick has only days to live, the team must diagnose and treat Matty before it's too late for both brothers.

Meanwhile, Foreman is haunted by his mistake that killed a patient just one week earlier, and House only wishes he could incur similar misfortune upon his new pet and nemesis, Hector.

Source: FOX

Addie, a 19-year-old college student, is admitted to Princeton Plainsboro after coughing up a mouthful of blood during karate class. Before treating the patient, Foreman unapologetically informs the rest of the team that he is resigning, but will not say why.

House strongly believes an infection is to blame for Addie's bleeding, even though her symptoms indicate otherwise. When Addie's lungs suddenly fill with fluid, the team believes that cancer or toxins could be an underlying cause, but House refuses to stray from his initial infection diagnosis. As Addie's condition worsens, House suggests a risky life-or-death treatment to confirm his suspected diagnosis, leaving the team wondering whether he cares more about making a diagnosis than he does about saving Addie's life.

Meanwhile, House takes a special interest in a young, attractive nutritionist named Honey, who accompanied her boyfriend to the clinic for treatment. Knowing he will have a position open soon on his team, House has Honey fill out an employment application and sees to it they meet again under more casual circumstances.

Source: FOX

Obnoxious 16-year-old chess prodigy Nate is admitted to Princeton-Plainsboro suffering from intense head pain that came on after he attacked his opponent during a speed chess tournament. Nate's mother tells the team that Nate has been having behavior problems ever since he became a teenager, and House suspects the behavior is a symptom of cluster headaches. As House's team carries out further testing to see why he might be having the headaches, Nate manages to offend and annoy each doctor on the team. As Nate's illness progresses, his liver and kidneys begin to fail. To narrow down the list of possible diagnoses, House carries out a series of unconventional and eccentric tests of his own, including engaging Nate in a game of chess to try to beat him at his own game. Meanwhile, Foreman's frustration with House reaches a new level when he believes House sabotaged his job interview with another hospital, and Cuddy makes Foreman an offer she's sure he can't refuse.



Source: FOX

A Cuban couple flee to America to find Dr. Gregory House, as the wife is suffering from undiagnosed illness. However, when they finally get there they find that House can do little for them. Meanwhile, the staff deal with Foreman's departure, which heralds the first of several radical changes in the staff.