House undergoes treatment for his hallucinations at Mayfield Psychiatric Hospital, and quickly declares himself cured and ready to leave. The doctor in charge, Darryl Nolan, disagrees and forces House to stay by threatening not to recertify his license until he believes House is cured. A battle of wills begins until House draws closer to the sister-in-law of a catatonic patient, endangers another patient, and admits that he actually does need help.

House resigns his position as chief diagnostician at Princeton, much to the surprise of his co-workers. Foreman immediately leaps in to take command and is given one chance to prove himself. However, his first case is a videogame magnate suffering from burning hands and swollen lymph nodes, and insists on consulting the Internet for medical solutions. Meanwhile, Thirteen tries to reconcile herself with this new side of her boyfriend, Taub looks for employment elsewhere, and Wilson discovers that his new roommate is obsessed with cooking.

When a brutal dictator visiting the U.S. falls ill, the government brings him to Princeton. Foreman is forced to bring in Cameron and Chase to help with the differential, and House returns to announce he wants his job back. Foreman tries to deal with House, and Cameron and Chase try to deal with the repercussions of their decision to try and heal the dictator. Meanwhile, Wilson tries to deal with an obnoxious neighbor who has taken an instant dislike to House.

When an oil executive's son suffers inexplicable symptoms, the man brings him to Princeton and insists that House treat him. House continues to take an advisory role while Foreman leads the team. Meanwhile, Foreman Chase try to cover up the events leading to President Dibala's death, and Hadley tries to figure out who wants to keep her at the hospital.

Cameron takes on the case of a reckless police detective who believes he will die at age 40 because of a family history of sudden heart failure that killed his father, grandfather and great-grandfather at the same age. The team takes on the case despite House's insistence it is coincidence. Meanwhile,Chase is haunted by his actions in the Dibala case, and House hears voices.

A teenager is admitted due to swollen joints but soon suffers from bleeding of the liver. It soon turns out that she is unable to tell the truth due to blood leakage into her thalamus. While Foreman, Cameron, and Chase try to solve the case, House attends a medical conference with Wilson and Cuddy and tries to start a relationship with his superior.

House gets his license and his position back and insists on taking the case of Hank Hardwick, a porn star stricken with photo-sensitivity. When Cameron and Chase announce that they're leaving, House schemes to convince them to stay and bring back Taub and Thirteen as well.

An accomplished physics prodigy, James Sidas, suffering from burnout, is stricken by an unknown disease while working as a courier. House realizes that the physicist has turned his back on his own intelligence. Meanwhile, Cuddy navigates around House's attempted interference in her relationship with Lucas, Chase deals with the aftermath of his marriage's breakup, and Taub takes steps to prevent the destruction of his marriage.

When Wilson's friend and former leukemia patient Tucker suffers paralysis of the arm, Wilson initially insists it's something other than cancer. House disagrees and offers a wager. However, when Wilson discovers what Tucker's illness really is, he has to decide whether to make a personal sacrifice to help Tucker live. Meanwhile, Cuddy tries to buy a house for herself and Lucas.

A drug dealer collapses in the middle of a sale, and his partner takes him to the hospital clinic for treatment. House soon realizes what they do for a living, and Mickey collapses again. The patient refuses to give up any information about his past, and House is determined to get at the truth. Meanwhile, Foreman learns that his teammates are all making more money and tries to negotiate with Cuddy. And House and Wilson vie for the affections of an attractive neighbor, only to discover that she believes they're homosexuals living together.

House and his team take on the case of an ailing businesswoman, Valerie, who suffers from ear pains. As her condition worsens, the doctors realize that Valerie is a clinical psychopath. However, they're not sure if it's a symptom or a psychological condition... and time is running out.

When a college football player goes berserk on the field, the team try to diagnose but he continues to get worse despite their best efforts. Meanwhile, House hires Foreman's brother, a recently-released convict, to get a rise out of Foreman. And House and Wilson engage in a war of pranks.

Dr. Lisa Cuddy has to deal with an ailing daughter, insurance negotiations, a nervous board of directors, a thieving pharmaceutical aide, warring surgeons, and... House, in what proves to be anything but a typical day at the hospital.

A blogger comes down with bruising and bleeding from the gums, and insists on posting her ailments on the illness despite her boyfriend's wishes. As he tries to solve the case, House discovers a dark secret from Wilson's past and can't resist telling everyone. Wilson seeks revenge and learns a secret about House. Meanwhile, Chase worries that he might be too good-looking.

House and the team try to diagnose a high school girl suffering from a rapidly escalating series of symptoms. Meanwhile, Taub tries to demonstrate to his wife that she can trust him after his philandering, and House dares Wilson to decorate the condo by himself.

When a newborn is abducted, Princeton goes into lockdown, and the staff find themselves trapped together. House deals with a dying patient, Taub and Foreman check the personnel records, Cameron asks Chase to sign their divorce papers, and Wilson and Thirteen play Truth or Dare.

When a medieval reenactment knight, Sir William, collapses during a battle, the team takes on the case and Thirteen is intrigued by William's insistence on honor above all else. Meanwhile, House discovers that Wilson is dating his first ex-wife, the "soul-sucking harpy," and vows to break them up to protect Wilson from himself.

Julia and Tom have a happy--and open--marriage. However, when Julia is stricken with abdominal pains, and her condition gets worse, House and his team must find out if honesty is all that it's cracked up to be, and if the happy honest couple actually have a honest marriage. Meanwhile, Wilson and Sam have an argument, and Rachel Taub wonders if her husband wants an open marriage.

When a groom collapses at the altar, the team discover that he harbors a secret that will affect their diagnosis. Meanwhile, Wilson pays House's team to take him out, and Taub tries to have an affair despite House's interference.

House meets with Dr. Nolan, who is intrigued when House insists on describing the case of an amnesiac woman suffering from what appears to be a quick-spreading prion infection. It soon becomes clear that House has more on his mind than just his patient's health.

House reluctantly accompanies Cuddy and emergency teams to the site of a crane accident. However, he's more interested in diagnosing the crane operator back at the hospital than dealing with the injured victims... until a trapped victim must decide whether to allow her leg to be amputated to save her life.